Factors associated with vasovagal reactions in apheresis plasma and whole blood donors: a statistical-epidemiological study in a European donor cohort
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چکیده
Total N of donation 30,868 23,674 N of individual donors 11,912 4,840 Median (IQR) N of donations per donor 2 (1–3) 4 (2–6) <0.001 Male : Female (%) 53 : 47 64 : 36 <0.001 Age, median (IQR) 37 (25–50) 41 (28–52) <0.001 N of VVRs (% of all donations) 108 (0.35) 245 (1.03) <0.001 N of donors with VVRs (% of all donors) 106 (0.89) 233 (4.81) <0.001 VVR rate by gender, ratio (%) Male (%) 54/16,454 (0.33) 114/15,151 (0.75) <0.001 Female (%) 54/14,414 (0.37) 131/8,523 (1.54) <0.001 P c) 0.490 <0.001 VVR rate by age, ratio (%) 17–20 yr 21/1,415 (1.48) 3/385 (0.78) 0.285 20–29 yr 62/9,931 (0.62) 108/6,299 (1.71) <0.001 30–39 yr 14/5,509 (0.25) 27/4,422 (0.61) 0.006 40–49 yr 8/5,873 (0.14) 52/5,079 (1.02) <0.001 50–59 yr 2/5,353 (0.04) 41/4,702 (0.87) <0.001 60–66 yr 1/2,787 (0.04) 14/2,787 (0.50) 0.001 VVR rate by season, ratio (%) Spring (Mar-May) 18/5,591 (0.32) 54/5,023 (1.08) <0.001 Summer (Jun-Aug) 38/8,308 (0.46) 80/6,854 (1.17) <0.001 Autumn (Sep-Nov) 31/9,382 (0.33) 62/6,077 (1.02) <0.001 Winter (Dec-Feb) 21/7,587 (0.28) 49/5,720 (0.86) <0.001 P d) 0.052 0.199 Re-donation rate, ratio (%) Donors without VVR 7,773/11,806 (65.8) 3,726/4,607 (80.9) <0.001 Donors with VVR 23/106 (21.7) 89/233 (38.2) 0.003 P e) <0.001 <0.001
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